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Melanoma: Hot or Cold for Immunotherapy

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Scientists have discovered a new way to predict which melanomas are hot or cold. Tumors with mutations in genes leading to over-activation of the NF-kB signaling pathway were more than three times as likely to respond to anti-PD1 immunotherapy compared with tumors in which these changes were absent, stated a University of Colorado Cancer Center study presented at the American Association for Cancer Research (AACR) Annual Meeting 2019. The problem is that it's been impossible to distinguish ...

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